Ontology highlight
ABSTRACT:
SUBMITTER: Jureczek J
PROVIDER: S-EPMC7297505 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Jureczek Justyna J Feldmann Anja A Bergmann Ralf R Arndt Claudia C Berndt Nicole N Koristka Stefanie S Loureiro Liliana Rodrigues LR Mitwasi Nicola N Hoffmann Anja A Kegler Alexandra A Bartsch Tabea T Bachmann Michael M
OncoTargets and therapy 20200612
<h4>Introduction</h4>Since epithelial growth factor receptor (EGFR) overexpression is linked to a variety of malignancies, it is an attractive target for immune therapy including chimeric antigen receptor (CAR)-engineered T cells. Unfortunately, CAR T cell therapy harbors the risk of severe, even life-threatening side effects. Adaptor CAR T cell platforms such as the previously described UniCAR system might be able to overcome these problems. In contrast to conventional CARs, UniCAR T cells are ...[more]