Ontology highlight
ABSTRACT:
SUBMITTER: Das SG
PROVIDER: S-EPMC7297540 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Das Suman G SG Direito Susana Ol SO Waclaw Bartlomiej B Allen Rosalind J RJ Krug Joachim J
eLife 20200519
Fitness effects of mutations depend on environmental parameters. For example, mutations that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the absence of antibiotic, exemplifying a tradeoff between adaptation to environmental extremes. We develop a mathematical model for fitness landscapes generated by such tradeoffs, based on experiments that determine the antibiotic dose-response curves of <i>Escherichia coli</i> strains, and previous observations on a ...[more]