Prognostic and Clinicopathological Correlations of Cell Cycle Marker Expressions before and after the Primary Systemic Therapy of Breast Cancer.
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ABSTRACT:
SUBMITTER: Tokes T
PROVIDER: S-EPMC7297700 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Prognostic and Clinicopathological Correlations of Cell Cycle Marker Expressions before and after the Primary Systemic Therapy of Breast Cancer.
Tőkés Tímea T Tőkés Anna-Mária AM Szentmártoni Gyöngyvér G Kiszner Gergő G Mühl Dorottya D Molnár Béla Ákos BÁ Kulka Janina J Krenács Tibor T Dank Magdolna M
Pathology oncology research : POR 20190824 3
We aimed to analyze the expression of cell-cycle regulation markers - minichromosome maintenance protein 2 (MCM2), Ki-67, Cyclin-A and phosphohistone-H3 (PHH3) - in pre-treatment core-biopsy samples of breast carcinomas in correlation with known predictive and prognostic factors. Totally 52 core biopsy samples obtained prior to neoadjuvant therapy were analyzed. Immunohistochemistry was performed to analyze the expression of MCM2, Ki-67, Cyclin A and PHH3, which were correlated with the followin ...[more]
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