Ontology highlight
ABSTRACT:
SUBMITTER: Zafar H
PROVIDER: S-EPMC7298005 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200616 1
Recent studies combine two novel technologies, single-cell RNA-sequencing and CRISPR-Cas9 barcode editing for elucidating developmental lineages at the whole organism level. While these studies provided several insights, they face several computational challenges. First, lineages are reconstructed based on noisy and often saturated random mutation data. Additionally, due to the randomness of the mutations, lineages from multiple experiments cannot be combined to reconstruct a species-invariant l ...[more]