Assessment of Luminal and Basal Phenotypes in Bladder Cancer.
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ABSTRACT:
SUBMITTER: Guo CC
PROVIDER: S-EPMC7298008 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Assessment of Luminal and Basal Phenotypes in Bladder Cancer.
Guo Charles C CC Bondaruk Jolanta J Yao Hui H Wang Ziqiao Z Zhang Li L Lee Sangkyou S Lee June-Goo JG Cogdell David D Zhang Miao M Yang Guoliang G Dadhania Vipulkumar V Choi Woonyoung W Wei Peng P Gao Jianjun J Theodorescu Dan D Logothetis Christopher C Dinney Colin C Kimmel Marek M Weinstein John N JN McConkey David J DJ Czerniak Bogdan B
Scientific reports 20200616 1
Genomic profiling studies have demonstrated that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and sensitivities to frontline chemotherapy. We analyzed the mRNA expressions of signature luminal and basal genes in bladder cancer tumor samples from publicly available and MD Anderson Cancer Center cohorts. We developed a quantitative classifier referred to as basal to luminal transition (BLT) score which identified the mo ...[more]
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