Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis.
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SUBMITTER: Besnier E
PROVIDER: S-EPMC7298868 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis.
Besnier Emmanuel E Coquerel David D Kouadri Geoffrey G Clavier Thomas T Favory Raphael R Duburcq Thibault T Lesur Olivier O Bekri Soumeya S Richard Vincent V Mulder Paul P Tamion Fabienne F
Critical care (London, England) 20200616 1
<h4>Background</h4>Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)).<h4>Methods</h4>Three groups were analyzed (n = 10/group): sham, CLP-NaCl 0.9%, and CLP-HSL (2.5 mL/kg/h of fluids for 18 h after CLP). Mesenteric microcirculation, echocardiography, cytokines, and biochemical parameters were evaluated. Two additional experiments were performed for capillary leakage (Eva ...[more]
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