Ontology highlight
ABSTRACT:
SUBMITTER: Lin P
PROVIDER: S-EPMC7299153 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Lin Ping P Qin Shugang S Pu Qinqin Q Wang Zhihan Z Wu Qun Q Gao Pan P Schettler Jacob J Guo Kai K Li Rongpeng R Li Guoping G Huang Canhua C Wei Yuquan Y Gao George Fu GF Jiang Jianxin J Wu Min M
Molecular cell 20200428 5
Cas13 has demonstrated unique and broad utility in RNA editing, nucleic acid detection, and disease diagnosis; however, a constantly active Cas enzyme may induce unwanted effects. Bacteriophage- or prophage-region-encoded anti-CRISPR (acr) gene molecules provide the potential to control targeting specificity and potency to allow for optimal RNA editing and nucleic acid detection by spatiotemporally modulating endonuclease activities. Using integrated approaches to screen acrVI candidates and eva ...[more]