Ontology highlight
ABSTRACT:
SUBMITTER: Miguez-Cabello F
PROVIDER: S-EPMC7299370 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
eLife 20200526
AMPARs control fast synaptic communication between neurons and their function relies on auxiliary subunits, which importantly modulate channel properties. Although it has been suggested that AMPARs can bind to TARPs with variable stoichiometry, little is known about the effect that this stoichiometry exerts on certain AMPAR properties. Here we have found that AMPARs show a clear stoichiometry-dependent modulation by the prototypical TARP γ2 although the receptor still needs to be fully saturated ...[more]