Unknown

Dataset Information

0

Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA.


ABSTRACT: Unlimited access to calorie-dense, palatable food is a hallmark of Western societies and substantially contributes to the worldwide rise of metabolic disorders. In addition to promoting overconsumption, palatable diets dampen daily intake patterns, further augmenting metabolic disruption. We developed a paradigm to reveal differential timing in the regulation of food intake behavior in mice. While homeostatic intake peaks in the active phase, conditioned place preference and choice experiments show an increased sensitivity to overeating on palatable food during the rest phase. This hedonic appetite rhythm is driven by endogenous circadian clocks in dopaminergic neurons of the ventral tegmental area (VTA). Mice with disrupted clock function in the VTA lose their hedonic overconsumption rhythms without affecting homeostatic intake. These findings assign a functional role of VTA clocks in modulating palatable feeding behaviors and identify a potential therapeutic route to counteract hyperphagy in an obesogenic environment.

SUBMITTER: Koch CE 

PROVIDER: S-EPMC7299974 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA.

Koch C E CE   Begemann K K   Kiehn J T JT   Griewahn L L   Mauer J J   M E Hess   Moser A A   Schmid S M SM   Brüning J C JC   Oster H H  

Nature communications 20200617 1


Unlimited access to calorie-dense, palatable food is a hallmark of Western societies and substantially contributes to the worldwide rise of metabolic disorders. In addition to promoting overconsumption, palatable diets dampen daily intake patterns, further augmenting metabolic disruption. We developed a paradigm to reveal differential timing in the regulation of food intake behavior in mice. While homeostatic intake peaks in the active phase, conditioned place preference and choice experiments s  ...[more]

Similar Datasets

| S-EPMC4785873 | biostudies-literature
| S-EPMC6345743 | biostudies-literature
| S-EPMC5727490 | biostudies-literature
2004-10-14 | GSE1837 | GEO
| S-EPMC5915959 | biostudies-literature
| S-EPMC6672311 | biostudies-literature
| S-EPMC9502544 | biostudies-literature
| S-EPMC4089089 | biostudies-literature
| S-EPMC8062589 | biostudies-literature
| S-EPMC3687134 | biostudies-literature