Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses.

ABSTRACT: Members of the leukocyte common antigen-related receptor protein tyrosine phosphatase (LAR-RPTP) family, comprising PTP?, PTP? and LAR, are key hubs for presynaptic assembly and differentiation in vertebrate neurons. However, roles of individual LAR-RPTP members have not been investigated using member-specific conditional knockout mice. Here, we show that loss of PTP? had no overt effect on synapse development in mouse cultured hippocampal neurons. Moreover, loss of PTP? in presynaptic CA1 hippocampal neurons did not influence neurotransmitter release in subicular pyramidal neurons, suggesting that PTP? is not critical for presynaptic function in vivo. Our results demonstrate that PTP? is not essential for synapse maintenance or transmission, at least in the mouse hippocampus, and underscore the importance of using sophisticated genetic approaches to confirm the roles of synaptic proteins.

SUBMITTER: Han KA 

PROVIDER: S-EPMC7301452 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature