Ontology highlight
ABSTRACT:
SUBMITTER: Lindner SE
PROVIDER: S-EPMC7301639 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Lindner Silke E SE Egelston Colt A CA Huard Stephanie M SM Lee Peter P PP Wang Leo D LD
ImmunoHorizons 20200520 5
Rho family GTPases are critical for normal B cell development and function, and their activity is regulated by a large and complex network of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). However, the role of GAPs in B cell development is poorly understood. In this study, we show that the novel Rac-GAP ARHGAP25 is important for B cell development in mice in a CXCR4-dependent manner. We show that <i>Arhgap25</i> deficiency in mice leads to a significant decreas ...[more]