Ontology highlight
ABSTRACT:
SUBMITTER: Chaikeeratisak V
PROVIDER: S-EPMC7301877 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chaikeeratisak Vorrapon V Khanna Kanika K Nguyen Katrina T KT Sugie Joseph J Egan MacKennon E ME Erb Marcella L ML Vavilina Anastasia A Nonejuie Poochit P Nieweglowska Eliza E Pogliano Kit K Agard David A DA Villa Elizabeth E Pogliano Joe J
Cell 20190601 7
Cargo trafficking along microtubules is exploited by eukaryotic viruses, but no such examples have been reported in bacteria. Several large Pseudomonas phages assemble a dynamic, tubulin-based (PhuZ) spindle that centers replicating phage DNA sequestered within a nucleus-like structure. Here, we show that capsids assemble on the membrane and then move rapidly along PhuZ filaments toward the phage nucleus for DNA packaging. The spindle rotates the phage nucleus, distributing capsids around its su ...[more]