Ontology highlight
ABSTRACT:
SUBMITTER: Tsai AG
PROVIDER: S-EPMC7301910 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Tsai Albert G AG Glass David R DR Juntilla Marisa M Hartmann Felix J FJ Oak Jean S JS Fernandez-Pol Sebastian S Ohgami Robert S RS Bendall Sean C SC
Nature medicine 20200311 3
The diagnosis of lymphomas and leukemias requires hematopathologists to integrate microscopically visible cellular morphology with antibody-identified cell surface molecule expression. To merge these into one high-throughput, highly multiplexed, single-cell assay, we quantify cell morphological features by their underlying, antibody-measurable molecular components, which empowers mass cytometers to 'see' like pathologists. When applied to 71 diverse clinical samples, single-cell morphometric pro ...[more]