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Increased functional dynamics in civil aviation pilots: Evidence from a neuroimaging study.

ABSTRACT: Civil aviation is a distinctive career. Pilots need to monitor the entire system in real time. However, the psychophysiological mechanism of flying is largely unknown. The human brain is a large-scale interconnected organization, and many stable intrinsic large-scale brain networks have been identified. Among them are three core neurocognitive networks: default mode network (DMN), central executive network (CEN), and salience network (SN). These three networks play a critical role in human cognition. This study aims to examine the dynamic properties of the three large-scale brain networks in civil aviation pilots. We collected resting-state functional magnetic resonance imaging data from pilots. Independent component analysis, which is a data-driven approach, was combined with sliding window dynamic functional connectivity analysis to detect the dynamic properties of large-scale brain networks. Our results revealed that pilots exhibit an increased interaction of the CEN with the DMN and the SN along with a decreased interaction within the CEN. In addition, the temporal properties of functional dynamics (number of transitions) increased in pilots compared to healthy controls. In general, pilots exhibited increased between-network functional connectivity, decreased within-network functional connectivity, and a higher number of transitions. These findings suggest that pilots might have better functional dynamics and cognitive flexibility.

SUBMITTER: Chen X

PROVIDER: S-EPMC7302522 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Increased functional dynamics in civil aviation pilots: Evidence from a neuroimaging study.

Chen Xi X Wang Quanchuan Q Luo Cheng C Yang Yong Y Jiang Hao H Guo Xiangmei X Chen Xipeng X Yang Jiazhong J Xu Kaijun K

PloS one 20200618 6

Civil aviation is a distinctive career. Pilots need to monitor the entire system in real time. However, the psychophysiological mechanism of flying is largely unknown. The human brain is a large-scale interconnected organization, and many stable intrinsic large-scale brain networks have been identified. Among them are three core neurocognitive networks: default mode network (DMN), central executive network (CEN), and salience network (SN). These three networks play a critical role in human cogni ...[more]

PMID: 32555721

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Project description:BACKGROUND:A challenge facing clinical neuroscientists is how best to synthesize diverse and sometimes inconsistent evidence for neuropsychological deficits and brain system dysfunction found in psychiatric disorders into models that guide etiological and treatment research. Multiple-pathway models suggest that psychiatric symptoms might arise from pathophysiology in different neural systems. This study tested dual-pathway model predictions for attention-deficit/hyperactivity disorder (ADHD) that reward and executive function cognitive deficits should be related to abnormalities in corresponding functionally specialized neural systems. METHODS:Behavioral inhibition and preference for immediate rewards were assessed in N = 251 adolescent boys and girls ages 12 to 18 diagnosed with DSM-IV combined-subtype ADHD or non-ADHD control subjects. Following taxometric analyses of test performance, the resulting subgroups were compared on a functional magnetic resonance imaging monetary incentive delay task probing reward anticipation and go/no-go task of motor response inhibition. RESULTS:Three ADHD subgroups were identified consistent with different proposed pathways-ADHD with executive function/motor inhibition deficits, ADHD with both executive and reward deficits, and ADHD with relatively normal test performance. Each cognitive domain mapped to different ADHD brain dysfunction features as expected. However, no brain abnormalities were found common to all ADHD subgroups despite the fact they had nearly identical ADHD-related clinical characteristics. CONCLUSIONS:The results suggest that combined-subtype ADHD is a collection of discrete disorders for which a comparable behavioral end point arises through different neurobiological pathways. The findings raise caution about applying common cause, single-deficit conceptual models to individual ADHD patients and should prompt researchers to consider biologically defined, multifactorial etiological models for other psychiatric diagnoses.

Dataset Information

Increased functional dynamics in civil aviation pilots: Evidence from a neuroimaging study.

Publications

Increased functional dynamics in civil aviation pilots: Evidence from a neuroimaging study.

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