Ontology highlight
ABSTRACT:
SUBMITTER: Norden PR
PROVIDER: S-EPMC7302880 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Norden Pieter R PR Sabine Amélie A Wang Ying Y Demir Cansaran Saygili CS Liu Ting T Petrova Tatiana V TV Kume Tsutomu T
eLife 20200608
Mutations in the transcription factor <i>FOXC2</i> are predominately associated with lymphedema. Herein, we demonstrate a key role for related factor FOXC1, in addition to FOXC2, in regulating cytoskeletal activity in lymphatic valves. FOXC1 is induced by laminar, but not oscillatory, shear and inducible, endothelial-specific deletion impaired postnatal lymphatic valve maturation in mice. However, deletion of <i>Foxc2</i> induced valve degeneration, which is exacerbated in <i>Foxc1; Foxc2</i> mu ...[more]