Ontology highlight
ABSTRACT:
SUBMITTER: Chottekalapanda RU
PROVIDER: S-EPMC7303013 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Chottekalapanda Revathy U RU Kalik Salina S Gresack Jodi J Ayala Alyssa A Gao Melanie M Wang Wei W Meller Sarah S Aly Ammar A Schaefer Anne A Greengard Paul P
Molecular psychiatry 20200521 7
Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed drugs for mood disorders. While the mechanism of SSRI action is still unknown, SSRIs are thought to exert therapeutic effects by elevating extracellular serotonin levels in the brain, and remodel the structural and functional alterations dysregulated during depression. To determine their precise mode of action, we tested whether such neuroadaptive processes are modulated by regulation of specific gene expression progr ...[more]