ARFGAP1 promotes AP-2-dependent endocytosis.
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ABSTRACT:
SUBMITTER: Bai M
PROVIDER: S-EPMC3087831 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
ARFGAP1 promotes AP-2-dependent endocytosis.
Bai Ming M Gad Helge H Turacchio Gabriele G Cocucci Emanuele E Yang Jia-Shu JS Li Jian J Beznoussenko Galina V GV Nie Zhongzhen Z Luo Ruibai R Fu Lianwu L Collawn James F JF Kirchhausen Tomas T Luini Alberto A Hsu Victor W VW
Nature cell biology 20110417 5
COPI (coat protein I) and the clathrin-AP-2 (adaptor protein 2) complex are well-characterized coat proteins, but a component that is common to these two coats has not been identified. The GTPase-activating protein (GAP) for ADP-ribosylation factor 1 (ARF1), ARFGAP1, is a known component of the COPI complex. Here, we show that distinct regions of ARFGAP1 interact with AP-2 and coatomer (components of the COPI complex). Selectively disrupting the interaction of ARFGAP1 with either of these two co ...[more]
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