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Late Onset Metallosis after Revision Total Knee Arthroplasty with Metal-Backed Patellar Component In Situ.

ABSTRACT: We describe a small case series with severe metallosis after revision total knee arthroplasty (TKA) due to metal-backed patellar component failure. Metallosis is a rare complication after TKA, which may cause systemic and local symptoms. In our cases, diagnosis of metallosis was supported by radiographic imaging and aseptic aspiration. Two of our 3 cases were successfully revised; in the remaining case surgery was not desired because of her poor general condition. Based on these cases, we recommend performing regular checkups in case of a metal-backed patellar component to detect metallosis in an early stage, to prevent extensive revision surgery. Moreover, we recommend applying a low threshold to revise a metal-backed patellar component because of the severe consequences of metallosis that might occur.

SUBMITTER: Koonen L

PROVIDER: S-EPMC7303496 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Late Onset Metallosis after Revision Total Knee Arthroplasty with Metal-Backed Patellar Component In Situ.

Koonen Laurens L Duit-van den Belt Lotte L Veenstra Kirsten K van Hellemondt Gijs G

Arthroplasty today 20200404 2

We describe a small case series with severe metallosis after revision total knee arthroplasty (TKA) due to metal-backed patellar component failure. Metallosis is a rare complication after TKA, which may cause systemic and local symptoms. In our cases, diagnosis of metallosis was supported by radiographic imaging and aseptic aspiration. Two of our 3 cases were successfully revised; in the remaining case surgery was not desired because of her poor general condition. Based on these cases, we recomm ...[more]

PMID: 32577475

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Project description:BACKGROUND:The study of localized immune-related factors has proven beneficial for a variety of conditions, and one area of interest in the field of orthopaedics is the impact of implants and localized infections on immune response. Several cytokines have shown increased systemic concentrations (in serum/plasma) in response to implants and infection, but tissue-level cytokines have not been investigated as thoroughly. METHODS:This exploratory study investigated tissue-level cytokines in a cohort of patients (N?=?17) in response to total knee arthroplasty and total knee revision to better understand the immune response to implants and localized infection (e.g., prosthetic joint infection). The overall goal of this study was to provide insight into the localized cytokine response of tissues and identify tissue-level markers specific to inflammation caused by implants vs. inflammation caused by infection. Tissues were collected across several anatomical locations and assayed with a panel of 20 human inflammatory cytokines to understand spatial differences in cytokine levels. RESULTS:In this study, six cytokines were elevated in implanted joints, as compared to native joints: IL-10, IL-12p70, IL-13, IL-17A, IL-4, and TNF-? (p?<?0.05). Seven cytokines showed infection-dependent increases in localized tissues: IL-1?, IL-1?, IL-6, IL-8, MCP-1, MIP-1?, and MIP-1? (p?<?0.05). CONCLUSIONS:This study demonstrated that differences exist in tissue-level cytokines in response to presence of implant, and some cytokines were specifically elevated for infection; these responses may be informative of overall tissue health. These results highlight the utility of investigating localized cytokine concentrations to offer novel insights for total knee arthroplasty and total knee revision procedures, as well as their complications. Ultimately, this information could provide additional, quantitative measurements of tissue to aid clinical decision making and patient treatment options.

Dataset Information

Late Onset Metallosis after Revision Total Knee Arthroplasty with Metal-Backed Patellar Component In Situ.

Publications

Late Onset Metallosis after Revision Total Knee Arthroplasty with Metal-Backed Patellar Component In Situ.

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