Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC7303620 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Yang Liuliu L Han Yuling Y Nilsson-Payant Benjamin E BE Gupta Vikas V Wang Pengfei P Duan Xiaohua X Tang Xuming X Zhu Jiajun J Zhao Zeping Z Jaffré Fabrice F Zhang Tuo T Kim Tae Wan TW Harschnitz Oliver O Redmond David D Houghton Sean S Liu Chengyang C Naji Ali A Ciceri Gabriele G Guttikonda Sudha S Bram Yaron Y Nguyen Duc-Huy T DT Cioffi Michele M Chandar Vasuretha V Hoagland Daisy A DA Huang Yaoxing Y Xiang Jenny J Wang Hui H Lyden David D Borczuk Alain A Chen Huanhuan Joyce HJ Studer Lorenz L Pan Fong Cheng FC Ho David D DD tenOever Benjamin R BR Evans Todd T Schwartz Robert E RE Chen Shuibing S
Cell stem cell 20200619 1
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental platform comprised of cell and organoid derivatives from human pluripotent stem cells (hPSCs). A Spike-enabled pseudo-entry virus infects pancreatic endocrine cells, liver organoids, ...[more]