TNF-? inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis.
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ABSTRACT:
SUBMITTER: Yang M
PROVIDER: S-EPMC7304211 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
TNF-α inhibitor therapy can improve the immune imbalance of CD4+ T cells and negative regulatory cells but not CD8+ T cells in ankylosing spondylitis.
Yang Mingcan M Lv Qing Q Wei Qiujing Q Jiang Yutong Y Qi Jun J Xiao Min M Fang Linkai L Xie Ya Y Cao Shuangyan S Lin Zhiming Z Zhang Yanli Y Tu Liudan L Zhao Minjing M Pan Yunfeng Y Jin Ou O Gu Jieruo J
Arthritis research & therapy 20200619 1
<h4>Background</h4>Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, and the correlation between the efficacy of TNF-α inhibitor and changes in immune imbalance is unclear.<h4>Methods</h4>A total of 40 immune cells were tested with flow cytometry, and the results of 105 healthy control (HC) subjects, 177 active-stage AS patients, and 23 AS cases before and after 12 weeks of TNF-α inhibitor therapy (Anbainuo) were analyzed.<h4>Results</h4>Compa ...[more]
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