Ontology highlight
ABSTRACT:
SUBMITTER: Lin KY
PROVIDER: S-EPMC7305233 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Lin Kun-Yang KY Wang Wen-Der WD Lin Chi-Hung CH Rastegari Elham E Su Yu-Han YH Chang Yu-Tzu YT Liao Yung-Feng YF Chang Yi-Chieh YC Pi Haiwei H Yu Bo-Yi BY Chen Shu-Hwa SH Lin Chung-Yen CY Lu Mei-Yeh MY Su Tsu-Yi TY Tzou Fei-Yang FY Chan Chih-Chiang CC Hsu Hwei-Jan HJ
Nature communications 20200619 1
Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC loss. Suppression of Piwi expression in the young niche mimics the aged niche, causing retrotransposon depression and coincident activation of Toll-mediated signaling, which promotes Glycogen synthase k ...[more]