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Clinical epidemiological analyses of overweight/obesity and abnormal liver function contributing to prolonged hospitalization in patients infected with COVID-19.

ABSTRACT: BACKGROUND/OBJECTIVES:During the 2019 coronavirus disease (COVID-19) outbreak, obesity may contribute to COVID-19 transmission and deterioration. In addition, many patients with COVID-19 infection have suffered liver damage which might contribute to a worse prognosis. We conducted a clinical epidemiological analysis to investigate the association of overweight/obesity and abnormal liver function (ALF) with hospitalized duration in patients infected with COVID-19. SUBJECTS/METHODS:Fifty-eight patients with diagnosed COVID-19 (22 women & 36 men; average age: 49.2?±?13.1?yr) were included, and their clinical data were collected at The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang. Overweight/obesity was determined as body mass index (BMI) ?24?kg/m2, ALF was determined as alanine aminotransferase >40?U/L, and prolonged hospitalization was lasting more than the median value of the hospitalized days (19 days) in this population. RESULTS:The proportions of prolonged hospitalization were elevated in patients with overweight/obesity and ALF compared with those without overweight/obesity (62.1% versus 26.1%, P?=?0.010) and those without ALF (70.6% versus 41.5%, P?=?0.043). Kaplan-Meier analysis showed that the hospitalized duration was increased from the patients with neither overweight/obesity nor ALF to those with either overweight/obesity or ALF, and to those with both of overweight/obesity and ALF (mean with 95% confidence interval: 16.4 [14.5-18.3] versus 25.3 [21.6-29.1] versus 28.3 [24.6-32.0], P for trend?=?0.001). Being discharged from hospital in time was inversely and independently associated with BMI (hazard ratio [HR]?=?0.75, 95% CI: 0.63-0.90, P for trend?=?0.002) and ALT (HR?=?0.95, 95% CI: 0.92-0.99, P for trend?=?0.007). CONCLUSIONS:Present findings suggested that overweight/obesity and/or ALF contributed to predicting a probability of prolonged hospitalization in patients with COVID-19 infection, to whom extra attentions and precautions should be paid during clinical treatments.

SUBMITTER: Hu X

PROVIDER: S-EPMC7307495 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Clinical epidemiological analyses of overweight/obesity and abnormal liver function contributing to prolonged hospitalization in patients infected with COVID-19.

Hu Xiang X Pan Xiaoqiong X Zhou Wei W Gu Xuejiang X Shen Feixia F Yang Bo B Hu Zhen Z

International journal of obesity (2005) 20200622 8

<h4>Background/objectives</h4>During the 2019 coronavirus disease (COVID-19) outbreak, obesity may contribute to COVID-19 transmission and deterioration. In addition, many patients with COVID-19 infection have suffered liver damage which might contribute to a worse prognosis. We conducted a clinical epidemiological analysis to investigate the association of overweight/obesity and abnormal liver function (ALF) with hospitalized duration in patients infected with COVID-19.<h4>Subjects/methods</h4> ...[more]

PMID: 32572128

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Clinical epidemiological analyses of overweight/obesity and abnormal liver function contributing to prolonged hospitalization in patients infected with COVID-19.

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Clinical epidemiological analyses of overweight/obesity and abnormal liver function contributing to prolonged hospitalization in patients infected with COVID-19.

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