Ontology highlight
ABSTRACT:
SUBMITTER: West J
PROVIDER: S-EPMC7307613 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
West Jeffrey J You Li L Zhang Jingsong J Gatenby Robert A RA Brown Joel S JS Newton Paul K PK Anderson Alexander R A ARA
Cancer research 20200116 7
A new ecologically inspired paradigm in cancer treatment known as "adaptive therapy" capitalizes on competitive interactions between drug-sensitive and drug-resistant subclones. The goal of adaptive therapy is to maintain a controllable stable tumor burden by allowing a significant population of treatment-sensitive cells to survive. These, in turn, suppress proliferation of the less-fit resistant populations. However, there remain several open challenges in designing adaptive therapies, particul ...[more]