Unknown

Dataset Information

0

Comprehensive analysis of drugs to treat SARS?CoV?2 infection: Mechanistic insights into current COVID?19 therapies (Review).

ABSTRACT: The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID?19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID?19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts.

SUBMITTER: Nitulescu GM 

PROVIDER: S-EPMC7307820 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review).

Nitulescu George Mihai GM   Paunescu Horia H   Moschos Sterghios A SA   Petrakis Dimitrios D   Nitulescu Georgiana G   Ion George Nicolae Daniel GND   Spandidos Demetrios A DA   Nikolouzakis Taxiarchis Konstantinos TK   Drakoulis Nikolaos N   Tsatsakis Aristidis A  

International journal of molecular medicine 20200518 2

The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID‑19). This work represents an exhaustive and critical review of all available data on potential treatments for  ...[more]

Similar Datasets

Unknown Bradykinin-target therapies in SARS-CoV-2 infection: current evidence and perspectives.
| S-EPMC8795307 | biostudies-literature
Unknown Mechanistic insights into SARS-CoV-2 epidemic via revealing the features of SARS-CoV-2 coding proteins and host responses upon its infection.
| S-EPMC7558794 | biostudies-literature
Unknown Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout.
| S-EPMC4334109 | biostudies-literature
Unknown Antiparasitic Drugs against SARS-CoV-2: A Comprehensive Literature Survey.
| S-EPMC9320270 | biostudies-literature
Unknown Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of action.
| S-EPMC7544922 | biostudies-literature
Unknown Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials.
| S-EPMC7521454 | biostudies-literature
Unknown Control of complement-induced inflammatory responses to SARS-CoV-2 infection by anti-SARS-CoV-2 antibodies
| S-SCDT-10_1038-S44318-024-00061-0 | biostudies-other
Unknown Therapeutic drugs for SARS-CoV-2 treatment: Current state and perspective.
| S-EPMC7691844 | biostudies-literature
Unknown Systematic review of risk of SARS-CoV-2 infection and severity of COVID-19 with therapies approved to treat multiple sclerosis.
| S-EPMC8743352 | biostudies-literature
Clinical A Retrospective Cohort Study for Main Postoperative Complications After SARS-CoV-2 Infection
| 12454 | ecrin-mdr-crc