Ontology highlight
ABSTRACT:
SUBMITTER: Knez D
PROVIDER: S-EPMC7307930 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Knez Damijan D Colettis Natalia N Iacovino Luca G LG Sova Matej M Pišlar Anja A Konc Janez J Lešnik Samo S Higgs Josefina J Kamecki Fabiola F Mangialavori Irene I Dolšak Ana A Žakelj Simon S Trontelj Jurij J Kos Janko J Binda Claudia C Marder Mariel M Gobec Stanislav S
Journal of medicinal chemistry 20200122 3
The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of <i>cis-</i> and <i>trans</i>-1-propargyl-4-styrylpiperidines. While the <i>cis</i> isomers are potent human MAO-A inhibitors, the ...[more]