Ontology highlight
ABSTRACT:
SUBMITTER: Janus P
PROVIDER: S-EPMC7308270 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Janus Patryk P Toma-Jonik Agnieszka A Vydra Natalia N Mrowiec Katarzyna K Korfanty Joanna J Chadalski Marek M Widłak Piotr P Dudek Karolina K Paszek Anna A Rusin Marek M Polańska Joanna J Widłak Wiesława W
Cell death and differentiation 20200129 7
Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and upregulates its expression which induces apoptosis. Such a mode of PMAIP1 activation is not dependent on p53. Therefore, HSF1 not only can activate the expression of genes encoding cytoprotective heat shock proteins, which prevents apoptosis, but ...[more]