Ontology highlight
ABSTRACT:
SUBMITTER: Wen B
PROVIDER: S-EPMC4142251 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Wen Bin B Peng Junhui J Zuo Xiaobing X Gong Qingguo Q Zhang Zhiyong Z
Biophysical journal 20140801 4
Large-scale flexibility within a multidomain protein often plays an important role in its biological function. Despite its inherent low resolution, small-angle x-ray scattering (SAXS) is well suited to investigate protein flexibility and determine, with the help of computational modeling, what kinds of protein conformations would coexist in solution. In this article, we develop a tool that combines SAXS data with a previously developed sampling technique called amplified collective motions (ACM) ...[more]