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The lateral septum mediates kinship behavior in the rat.

ABSTRACT: Evolutionary theory and behavioral biology suggest that kinship is an organizing principle of social behavior. The neural mechanisms that mediate kinship behavior are, however, not known. Experiments confirm a sibling-approach preference in young rat pups and a sibling-avoidance-preference in older pups. Lesions of the lateral septum eliminate such kin preferences. In vivo juxta-cellular and whole-cell patch-clamp recordings in the lateral septum show multisensory neuronal responses to kin and non-kin stimuli. Non-kin odor-responsive neurons are located dorsally and kin-odor responsive neurons are located ventrally in the lateral septum. With development, the fraction of kin-responsive lateral septal neurons decrease and ongoing firing rates increase. Lesion effects, developmental changes and the ordered representation of response preferences according to kinship-an organization we refer to as nepotopy-point to a key role of the lateral septum in organizing mammalian kinship behavior.

SUBMITTER: Clemens AM

PROVIDER: S-EPMC7308382 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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The lateral septum mediates kinship behavior in the rat.

Clemens Ann M AM Wang Hong H Brecht Michael M

Nature communications 20200622 1

Evolutionary theory and behavioral biology suggest that kinship is an organizing principle of social behavior. The neural mechanisms that mediate kinship behavior are, however, not known. Experiments confirm a sibling-approach preference in young rat pups and a sibling-avoidance-preference in older pups. Lesions of the lateral septum eliminate such kin preferences. In vivo juxta-cellular and whole-cell patch-clamp recordings in the lateral septum show multisensory neuronal responses to kin and n ...[more]

PMID: 32572024

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