T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients.

ABSTRACT: Little is known about cell-mediated immune responses to natural influenza infection in solid organ transplant (SOT) patients. The aim of our study was to evaluate the CD4⁺ and CD8⁺ responses to influenza A and B infection in a cohort of SOT patients. We collected peripheral blood mononuclear cells at influenza diagnosis and four weeks later from 31 SOT patients during the 2017-2018 influenza season. Infection-elicited influenza-specific CD4⁺ and CD8⁺ T-cell responses were measured using flow cytometry and intracellular cytokine staining and compared to responses following influenza vaccine in SOT patients. Natural infection was associated with a significant increase in CD4⁺ T-cell responses. For example, polyfunctional cells increased

SUBMITTER: L'Huillier AG 

PROVIDER: S-EPMC7308384 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature