Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC7309633 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Biochemistry 20190826 36
Base editing is a genome editing strategy that induces specific single-nucleotide changes within genomic DNA. Two major DNA base editors, cytosine base editors and adenine base editors, that consist of a Cas9 protein linked to a deaminase enzyme that catalyzes targeted base conversion directed by a single-guide RNA have been developed. This strategy has been used widely for precise genome editing because, unlike CRISPR-Cas nuclease-based genome editing systems, this strategy does not create doub ...[more]