Ontology highlight
ABSTRACT:
SUBMITTER: Xia Y
PROVIDER: S-EPMC7310041 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Xia Yuxing Y Prokop Stefan S Gorion Kimberly-Marie M KM Kim Justin D JD Sorrentino Zachary A ZA Bell Brach M BM Manaois Alyssa N AN Chakrabarty Paramita P Davies Peter P Giasson Benoit I BI
Acta neuropathologica communications 20200622 1
Tau protein abnormally aggregates in tauopathies, a diverse group of neurologic diseases that includes Alzheimer's disease (AD). In early stages of disease, tau becomes hyperphosphorylated and mislocalized, which can contribute to its aggregation and toxicity. We demonstrate that tau phosphorylation at Ser208 (pSer208) promotes microtubule dysfunction and tau aggregation in cultured cells. Comparative assessment of the epitopes recognized by antibodies AT8, CP13, and 7F2 demonstrates that CP13 a ...[more]