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Identification of plasmid IncQ1 and NTEKPC-IId harboring bla KPC-2 in isolates from Klebsiella pneumoniae infections in patients from Recife-PE, Brazil.

ABSTRACT: INTRODUCTION:This study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODS:Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing. RESULTS:The bla KPC-2 gene was located between ISKpn6 and a resolvase tnpR in the non-Tn4401 element (NTEKPC-IId). It was detected on a plasmid belonging to the IncQ1 group. CONCLUSIONS:To our knowledge, this is the first report of the presence of the bla KPC-2 gene in the NTEKPC-IId element carried by plasmid IncQ1 from infections in Brazil.

SUBMITTER: Lima GJ 

PROVIDER: S-EPMC7310361 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Identification of plasmid IncQ1 and NTEKPC-IId harboring bla KPC-2 in isolates from Klebsiella pneumoniae infections in patients from Recife-PE, Brazil.

Lima Giselle Jucá de GJ   Scavuzzi Alexsandra Maria Lima AML   Beltrão Elizabeth Maria Bispo EMB   Firmo Elza Ferreira EF   Oliveira Érica Maria de ÉM   Oliveira Sibele Ribeiro de SR   Rezende Antônio Mauro AM   Lopes Ana Catarina de Souza ACS  

Revista da Sociedade Brasileira de Medicina Tropical 20200622

<h4>Introduction</h4>This study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates.<h4>Methods</h4>Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using polymerase chain reaction and plasmid DNA sequencing.<h4>Results</h4>The bla KPC-2 gene was located between ISKpn6 and a resolvase tnpR in the non-Tn4401 element (NTEKPC-IId). It was detected o  ...[more]

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