Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC7311176 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chen Zibo Z Johnson Matthew C MC Chen Jiajun J Bick Matthew J MJ Boyken Scott E SE Lin Baihan B De Yoreo James J JJ Kollman Justin M JM Baker David D DiMaio Frank F
Journal of the American Chemical Society 20190510 22
Modular self-assembly of biomolecules in two dimensions (2D) is straightforward with DNA but has been difficult to realize with proteins, due to the lack of modular specificity similar to Watson-Crick base pairing. Here we describe a general approach to design 2D arrays using de novo designed pseudosymmetric protein building blocks. A homodimeric helical bundle was reconnected into a monomeric building block, and the surface was redesigned in Rosetta to enable self-assembly into a 2D array in th ...[more]