Ontology highlight
ABSTRACT:
SUBMITTER: Banote RK
PROVIDER: S-EPMC7311384 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Banote Rakesh Kumar RK Chebli Jasmine J Şatır Tuğçe Munise TM Varshney Gaurav K GK Camacho Rafael R Ledin Johan J Burgess Shawn M SM Abramsson Alexandra A Zetterberg Henrik H
Scientific reports 20200623 1
Understanding the biological function of amyloid beta (Aβ) precursor protein (APP) beyond its role in Alzheimer's disease is emerging. Yet, its function during embryonic development is poorly understood. The zebrafish APP orthologue, Appb, is strongly expressed during early development but thus far has only been studied via morpholino-mediated knockdown. Zebrafish enables analysis of cellular processes in an ontogenic context, which is limited in many other vertebrates. We characterized zebrafis ...[more]