Ontology highlight
ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC7311394 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
He Yueqin Y Sun Xinlei X Rong Weiwei W Yang Rong R Liang Hongwei H Qi Ying Y Li Limin L Zen Ke K
Scientific reports 20200623 1
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in both human and mouse intestinal epithelium was upregulated in colitic condition compared to that under normal condition. In line with this, CD47 deficiency protected mice from DSS-induced colitis. Anal ...[more]