Asymmetry between Activators and Deactivators in Functional Protein Networks.
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ABSTRACT:
SUBMITTER: Tareen A
PROVIDER: S-EPMC7311538 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Asymmetry between Activators and Deactivators in Functional Protein Networks.
Tareen Ammar A Wingreen Ned S NS Mukhopadhyay Ranjan R
Scientific reports 20200623 1
Are "turn-on" and "turn-off" functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymme ...[more]
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