Elevated plasma neurofilament light in aging reflects brain white-matter alterations but does not predict cognitive decline or Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Nyberg L
PROVIDER: S-EPMC7311800 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Elevated plasma neurofilament light in aging reflects brain white-matter alterations but does not predict cognitive decline or Alzheimer's disease.
Nyberg Lars L Lundquist Anders A Nordin Adolfsson Annelie A Andersson Micael M Zetterberg Henrik H Blennow Kaj K Adolfsson Rolf R
Alzheimer's & dementia (Amsterdam, Netherlands) 20200623 1
<h4>Introduction</h4>We investigated neurofilament light (NFL) accumulation in normal aging as well as in preclinical and clinical Alzheimer's disease (AD) and assessed individual differences in NFL load in relation to cognition and brain white-matter integrity.<h4>Methods</h4>We analyzed longitudinal data covering 30 years (1988-2017). Cognitive testing was done up to six times. Plasma NFL was quantified for controls and 142 cases who developed AD over time, and longitudinal changes in NFL were ...[more]
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