Ontology highlight
ABSTRACT:
SUBMITTER: Frisch A
PROVIDER: S-EPMC7312290 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Frisch Anne A Kälin Stefanie S Monk Raymond R Radke Josefine J Heppner Frank L FL Kälin Roland E RE
International journal of molecular sciences 20200611 11
Glioblastoma (GBM) present with an abundant and aberrant tumor neo-vasculature. While rapid growth of solid tumors depends on the initiation of tumor angiogenesis, GBM also progress by infiltrative growth and vascular co-option. The angiogenic factor apelin (<i>APLN</i>) and its receptor (<i>APLNR</i>) are upregulated in GBM patient samples as compared to normal brain tissue. Here, we studied the role of apelin/APLNR signaling in GBM angiogenesis and growth. By functional analysis of apelin in o ...[more]