Ontology highlight
ABSTRACT:
SUBMITTER: Harford-Wright E
PROVIDER: S-EPMC5841205 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Harford-Wright Elizabeth E Andre-Gregoire Gwennan G Jacobs Kathryn A KA Treps Lucas L Le Gonidec Sophie S Leclair Heloise M HM Gonzalez-Diest Sara S Roux Quentin Q Guillonneau François F Loussouarn Delphine D Oliver Lisa L Vallette François M FM Foufelle Fabienne F Valet Philippe P Davenport Anthony P AP Glen Robert C RC Bidere Nicolas N Gavard Julie J
Brain : a journal of neurology 20171101 11
Glioblastoma are highly aggressive brain tumours that are associated with an extremely poor prognosis. Within these tumours exists a subpopulation of highly plastic self-renewing cancer cells that retain the ability to expand ex vivo as tumourspheres, induce tumour growth in mice, and have been implicated in radio- and chemo-resistance. Although their identity and fate are regulated by external cues emanating from endothelial cells, the nature of such signals remains unknown. Here, we used a mas ...[more]