Ontology highlight
ABSTRACT:
SUBMITTER: Al-Wahaibi LH
PROVIDER: S-EPMC7312570 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Al-Wahaibi Lamya H LH Al-Saleem Muneera S M MSM Ahmed Osama A A OAA Fahmy Usama A UA Alhakamy Nabil A NA Eid Basma G BG Abdel-Naim Ashraf B AB Abdel-Mageed Wael M WM AlRasheed Maha M MM Shazly Gamal A GA
International journal of molecular sciences 20200610 11
Accumulating evidence indicates that statins reduce the risk of different cancers and inhibit the proliferation of liver cancer cells. This study aims to explore whether the electrostatic conjugation of optimized fluvastatin (FLV) to human immunodeficiency virus type 1 (HIV-1) trans-activator transcription peptide (TAT) would enhance the anti-proliferative activity against HepG2 cells. FLV-TAT conjugation was optimized to achieve the lowest size with highest zeta potential. Nine formulae were co ...[more]