Ontology highlight
ABSTRACT:
SUBMITTER: Ouahoud S
PROVIDER: S-EPMC7313454 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Ouahoud Sarah S Hardwick James C H JCH Hawinkels Lukas J A C LJAC
International journal of molecular sciences 20200529 11
The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-β (TGF-β) superfamily, are involved in multiple biological processes such as embryonic development and maintenance of adult tissue homeostasis. The importance of a functional BMP pathway is underlined by various diseases, including cancer, which can arise as a consequence of dysregulated BMP signaling. Mutations in crucial elements of this signaling pathway, such as receptors, have been reported to disrupt BMP s ...[more]