Ontology highlight
ABSTRACT:
SUBMITTER: Brinson RG
PROVIDER: S-EPMC7313657 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Brinson Robert G RG Marino John P JP
Journal of magnetic resonance (San Diego, Calif. : 1997) 20190820
The higher order structure (HOS) of protein therapeutics is essential for drug safety and efficacy and can be evaluated by two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy at atomic resolution. <sup>1</sup>Hn-<sup>15</sup>N amide correlated and <sup>1</sup>H-<sup>13</sup>C methyl correlated NMR spectroscopies at natural isotopic abundance have been demonstrated as feasible on protein therapeutics as large as monoclonal antibodies and show great promise for use in establishing d ...[more]