Ontology highlight
ABSTRACT:
SUBMITTER: Yu S
PROVIDER: S-EPMC7314990 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Yu Shuang S Li Yihong Y Zhao Hongwei H Wang Qingdong Q Chen Ping P
Frontiers in physiology 20200618
The roles of the histone demethylase JMJD1C in cardiac hypertrophy remain unknown. JMJD1C was overexpressed in hypertrophic hearts of humans and mice, whereas the histone methylation was reduced. <i>Jmjd1c</i> knockdown repressed the angiotensin II (Ang II)-mediated increase in cardiomyocyte size and overexpression of hypertrophic genes in cardiomyocytes. By contrast, JMJD1C overexpression promoted the hypertrophic response of cardiomyocytes. Our further molecular mechanism study revealed that J ...[more]