Ontology highlight
ABSTRACT:
SUBMITTER: Pedram A
PROVIDER: S-EPMC3861078 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Pedram Ali A Razandi Mahnaz M Narayanan Ramesh R Dalton James T JT McKinsey Timothy A TA Levin Ellis R ER
Molecular biology of the cell 20131023 24
The development and progression of cardiac hypertrophy often leads to heart failure and death, and important modulators of hypertrophy include the histone deacetylase proteins (HDACs). Estrogen inhibits cardiac hypertrophy and progression in animal models and humans. We therefore investigated the influence of 17-β-estradiol on the production, localization, and functions of prohypertrophic (class I) and antihypertrophic (class II) HDACs in cultured neonatal rat cardiomyocytes. 17-β-Estradiol or e ...[more]