Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC7315187 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Chen Shuang S Markman Janet L JL Shimada Kenichi K Crother Timothy R TR Lane Malcolm M Abolhesn Amanda A Shah Prediman K PK Arditi Moshe M
JACC. Basic to translational science 20200520 6
In the <i>Ldlr</i> <sup><i>-/-</i></sup> mouse model of atherosclerosis, female <i>Nlrp3</i> <sup><i>-/-</i></sup> bone marrow chimera and <i>Nlrp3</i> <sup><i>-/-</i></sup> mice developed significantly smaller lesions in the aortic sinus and decreased lipid content in aorta en face, but a similar protection was not observed in males. Ovariectomized female mice lost protection from atherosclerosis in the setting of NLRP3 deficiency, whereas atherosclerosis showed a greater dependency on NLRP3 in ...[more]