Genomewide Association Study of Severe Covid-19 with Respiratory Failure.

ABSTRACT:

Background

There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19.

Methods

We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe. After quality control and the exclusion of population outliers, 835 patients and 1255 control participants from Italy and 775 patients and 950 control participants from Spain were included in the fina

SUBMITTER: Severe Covid-19 GWAS Group 

PROVIDER: S-EPMC7315890 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature