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Maternal high-fat diet regulates glucose metabolism and pancreatic ? cell phenotype in mouse offspring at weaning.


ABSTRACT: Background:Maternal malnutrition is a critical factor in determining the risk of obesity and glucose intolerance in offspring. However, little is known about the effects of a maternal high-fat diet (HFD) on the ? cell phenotype in offspring, which is a major factor in glucose homeostasis, especially during the early life of offspring. Methods:Dams were randomly fed a HFD (60% kcal from fat) or a chow diet before pregnancy and during gestation and lactation. Glucose metabolism and the ? cell phenotype were assessed in male offspring at weaning. Results:Dams fed a HFD showed impaired glucose tolerance. A HFD predisposed the offspring to increased impairment of metabolic health, including obesity, glucose intolerance and insulin resistance, compared with offspring from chow diet-fed dams. Furthermore, increased islet sizes and islet densities were observed in male offspring from HFD-fed dams at weaning. There were increases in the insulin-positive area, ? cell mass and ? cell proliferation in male offspring from HFD-fed dams at weaning age. Next, we further determined whether a maternal HFD could affect ? cell apoptosis in mouse offspring and found that there was no significant change in ? cell apoptosis between the HFD and control groups. Conclusion:Our study is novel in showing that a maternal HFD predisposes offspring to impaired glucose metabolism and has a profound effect on ? cell mass and proliferation in offspring mice, which is observed in mice as early as at weaning age. However, further study to clarify the underlying mechanisms is warranted.

SUBMITTER: Zheng J 

PROVIDER: S-EPMC7316079 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Maternal high-fat diet regulates glucose metabolism and pancreatic β cell phenotype in mouse offspring at weaning.

Zheng Jia J   Zhang Ling L   Wang Ziwei Z   Zhang Junqing J  

PeerJ 20200622


<h4>Background</h4>Maternal malnutrition is a critical factor in determining the risk of obesity and glucose intolerance in offspring. However, little is known about the effects of a maternal high-fat diet (HFD) on the β cell phenotype in offspring, which is a major factor in glucose homeostasis, especially during the early life of offspring.<h4>Methods</h4>Dams were randomly fed a HFD (60% kcal from fat) or a chow diet before pregnancy and during gestation and lactation. Glucose metabolism and  ...[more]

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