Unknown

Dataset Information

0

COVID-19 Hyperinflammation: What about Neutrophils?


ABSTRACT: COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The immunopathological mechanisms that cause excessive inflammation are under investigation and constantly updated. Here, a gene network approach was used on recently published data sets to identify possible COVID-19 inflammatory mechanisms and bioactive genes. First, network analysis of putative SARS-CoV-2 cellular receptors led to the mining of a neutrophil-response signature and relevant inflammatory genes. Second, analysis of RNA-seq data sets of lung cells infected with SARS-CoV-2 revealed that infected cells expressed neutrophil-attracting chemokines. Third, analysis of RNA-seq data sets of bronchoalveolar lavage fluid cells from COVID-19 patients identified upregulation of neutrophil genes and chemokines. Different inflammatory genes mined here, including TNFR, IL-8, CXCR1, CXCR2, ADAM10, GPR84, MME, ANPEP, and LAP3, might be druggable targets in efforts to limit SARS-CoV-2 inflammation in severe clinical cases. The possible role of neutrophils in COVID-19 inflammation needs to be studied further.

SUBMITTER: Didangelos A 

PROVIDER: S-EPMC7316488 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

COVID-19 Hyperinflammation: What about Neutrophils?

Didangelos Athanasios A  

mSphere 20200624 3


COVID-19 is often related to hyperinflammation that drives lung or multiorgan injury. The immunopathological mechanisms that cause excessive inflammation are under investigation and constantly updated. Here, a gene network approach was used on recently published data sets to identify possible COVID-19 inflammatory mechanisms and bioactive genes. First, network analysis of putative SARS-CoV-2 cellular receptors led to the mining of a neutrophil-response signature and relevant inflammatory genes.  ...[more]

Similar Datasets

| S-SCDT-EMM-2020-13038 | biostudies-other
| S-EPMC7732408 | biostudies-literature
| S-EPMC7484812 | biostudies-literature
| S-EPMC7490488 | biostudies-literature
2022-07-27 | PXD033293 | Pride
| S-EPMC7195984 | biostudies-literature
| S-EPMC8811745 | biostudies-literature
| S-EPMC7790268 | biostudies-literature
| S-EPMC8463930 | biostudies-literature
| S-EPMC8994846 | biostudies-literature