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Proteomic analysis neutrophils from COVID-19 patients

ABSTRACT: To go further insight into the involvement of neutrophils in COVID-19 clinical expression, we performed a proteomic analysis of this blood cell type in COVID-19 patients and two non-infected SARS-CoV-2 control groups composed of healthy subjects and ARDS patients hospitalized in intensive care unit (ICU) respectively. All patients were from Guadeloupe and represent a homogeneous population. We have performed a quantitative proteomic study of neutrophiles from French hot spot COVID region, Guadeloupe, confirming the activation of type I IFN pathway and in some target of IFN as TAP proteins, specifically in COVID patients, but not in hospitalized ARDS non-COVID patients and described modification of the NET proteome potentially associated with ARDS.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neutrophil, Blood

DISEASE(S): Severe Acute Respiratory Syndrome

SUBMITTER: Emilie-Fleur GAUTIER

LAB HEAD: Emilie-Fleur Gautier

PROVIDER: PXD033293 | Pride | 2022-07-27

REPOSITORIES: Pride

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			Action	DRS
	ClVK210419_CovidNeutro_DP016_MR_ExtNeutro_SCX1_C41165_RI14_1_2008.d.7z	Other
	ClVK210419_CovidNeutro_DP016_MR_ExtNeutro_SCX2_C41166_RI15_1_2009.d.7z	Other
	ClVK210419_CovidNeutro_DP016_MR_ExtNeutro_SCX3_C41167_RI16_1_2010.d.7z	Other
	ClVK210419_CovidNeutro_DP016_MR_ExtNeutro_SCX4_C41168_RI17_1_2011.d.7z	Other
	ClVK210419_CovidNeutro_DP016_MR_ExtNeutro_SCX5_C41169_RI18_1_2012.d.7z	Other

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Publications

Proteomic analysis of neutrophils from patients with COVID-19.

Romana Marc M Leduc Marjorie M Hermand Patricia P Bruce Johanna J Gautier Emilie-Fleur EF Martino Frédéric F Garnier Yohann Y Baccini Véronique V Le Van Kim Caroline C

British journal of haematology 20220711 1

PMID: 35818311

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