Ontology highlight
ABSTRACT:
SUBMITTER: Christidi E
PROVIDER: S-EPMC7316788 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Christidi Effimia E Huang Haojun H Shafaattalab Sanam S Maillet Agnes A Lin Eric E Huang Kate K Laksman Zachary Z Davis Margot K MK Tibbits Glen F GF Brunham Liam R LR
Scientific reports 20200625 1
Doxorubicin is a potent anticancer drug used to treat a variety of cancer types. However, its use is limited by doxorubicin-induced cardiotoxicity (DIC). A missense variant in the RARG gene (S427L; rs2229774) has been implicated in susceptibility to DIC in a genome wide association study. The goal of this study was to investigate the functional role of this RARG variant in DIC. We used induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) from patients treated with doxorubicin. iPSC-CM ...[more]